Journal article

LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

H Butzkueven, JG Zhang, MS Hanninen, H Hochrein, F Chionh, KA Shipham, B Emery, AM Turnley, S Petratos, M Ernst, PF Bartlett, TJ Kilpatrick

Nature Medicine | NATURE PUBLISHING GROUP | Published : 2002

Abstract

Multiple sclerosis (MS) is a disabling inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults. Available therapies can inhibit the inflammatory component of MS but do not suppress progressive clinical disability. An alternative approach would be to inhibit mechanisms that drive the neuropathology of MS, which often includes the death of oligodendrocytes, the cells responsible for myelinating the CNS. Identification of molecular mechanisms that mediate the stress response of oligodendrocytes to optimize their survival would serve this need. This study shows that the neurotrophic cytokine leukemia inhibitory factor (LIF) directly prevents oli..

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