Journal article
Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers
JC Hood, J Dowling, JF Bertram, RJ Young, C Huxtable, W Robinson, J Savige
NEPHROLOGY DIALYSIS TRANSPLANTATION | OXFORD UNIV PRESS | Published : 2002
Abstract
BACKGROUND: Bull terrier hereditary nephritis represents a model for autosomal dominant Alport syndrome, as affected dogs have the characteristically lamellated glomerular basement membrane and demonstrate vertical male-to-male disease transmission. METHODS: This study compared the histopathological features in kidneys from affected Bull terrier neonates, puppies, and adult dogs with normal or impaired renal function, with the histopathological appearance of kidneys from age- and size-matched normal dogs. RESULTS: There were fewer glomeruli per unit area of cortex in kidneys from affected neonatal kidneys (P<0.05), increased numbers of fetal glomeruli in affected puppy kidneys (P<0.05), and ..
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