Journal article

Human chorionic gonadotrophin (hCG) stimulates spermatogenesis in immature mice in vivo

BY Zhou, JM Hutson, LM Watts, S Hasthorpe, undefined Naim-Ul-Islam

JOURNAL OF PEDIATRIC SURGERY | W B SAUNDERS CO | Published : 2002

Abstract

BACKGROUND/PURPOSE: Spermatogenesis in postnatal testes is controlled by the hypothalamic-pituitary-gonadal axis. To determine if pituitary hormones can induce precocious spermatogenesis once primary spermatocytes (PS) have formed, prepubertal mice were treated with human chorionic gonadotrophin (hCG). METHODS: Day 12 immature mice (n = 10) were injected every third day with hCG (3 or 6 IU) dissolved in 100 microL phosphate-buffered saline (PBS). Control mice (n = 10) were either uninjected or injected with 100 microL PBS alone. On day 20 to 22 the excised testes were examined histologically with tubule counts. RESULTS: HCG-treated mice had fewer tubules at stage I (P <.001) and more at stag..

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