Journal article

Slow excitatory synaptic potentials evoked by distension in myenteric descending interneurones of guinea-pig ileum

PDJ Thornton, JC Bornstein

JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2002

Abstract

The functional significance of the slow excitatory synaptic potentials (EPSPs) in myenteric neurones is unknown. We investigated this using intracellular recording from myenteric neurones in guinea-pig ileum, in vitro. In all, 121 neurones responded with fast EPSPs to distension of the intestine oral to the recording site. In 28 of these neurones, distension also evoked depolarizations similar to the slow EPSPs evoked by electrical stimulation in the same neurones. Intracellular injection of biocytin and immunohistochemistry revealed that neurones responding to distension with slow EPSPs were descending interneurones, which were immunoreactive for nitric oxide synthase (NOS). Other neurones,..

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University of Melbourne Researchers