Journal article

Novel therapies for sarcopenia: ameliorating age-related changes in skeletal muscle

GS Lynch

EXPERT OPINION ON THERAPEUTIC PATENTS | TAYLOR & FRANCIS LTD | Published : 2002

Abstract

Among the most serious consequences of ageing are its effects on skeletal muscle structure and function. Ageing is associated with a progressive loss of muscle mass (sarcopenia) motor function, a slowing of muscle movements and a decline in muscle strength. These age-related changes in muscle properties contribute to the gradual loss of functional independence and the increased incidence of fall-related injuries in the elderly. Progressive muscle fibre denervation, the loss of motor units and subsequent motor unit remodelling have been implicated as mechanisms responsible for these deleterious effects of ageing on skeletal muscle, especially the loss of force and power output. However, the a..

View full abstract

University of Melbourne Researchers