Journal article

Temozolomide-induced flare in high-grade gliomas: a new clinical entity

MA Rosenthal, DL Ashley, L Cher

INTERNAL MEDICINE JOURNAL | BLACKWELL PUBLISHING ASIA | Published : 2002

Abstract

A transient deterioration in neurological status following commencement of chemotherapy for high-grade gliomas has not been previously described. We report eight cases of transient deterioration following administration of temozolomide, a relatively new cytotoxic agent used in the treatment of high-grade gliomas. We believe this represents the novel clinical entity of temozolomide-induced tumour flare.