Journal article

Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor

S Petratos, H Butzkueven, K Shipham, H Cooper, T Bucci, K Reid, E Lopes, B Emery, SS Cheema, TJ Kilpatrick

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | AMER ASSN NEUROPATHOLOGISTS INC | Published : 2003

Abstract

Schwann cell death is a developmentally regulated phenomenon and is also induced after peripheral nerve axotomy in neonatal rodents. In this study, we explored whether ligand-induced activation of the low-affinity neurotrophin receptor (p75(NTR)) is responsible for inducing Schwann cell death in vivo. Administration of exogenous nerve growth factor (NGF) to the axotomized nerve site in wild-type animals resulted in a 2.6-fold increase in Schwann cell apoptosis in the distal nerve stumps compared to axotomy alone. No increase in apoptosis, above baseline levels, was seen in p75(NTR)-mutant mice either with or without NGF When anti-NGF antibodies were administered to the site of the peripheral..

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