Screening for lung cancer: A systematic review and meta-analysis of controlled trials

Abstract

Background: Lung cancer is a substantial public health problem in western countries. Previous studies have examined different screening strategies for lung cancer but there have been no published systematic reviews. Methods: A systematic review of controlled trials was conducted to determine whether screening for lung cancer using regular sputum examinations or chest radiography or computed tomography (CT) reduces lung cancer mortality. The primary outcome was lung cancer mortality; secondary outcomes were lung cancer survival and all cause mortality. Results: One non-randomised controlled trial and six randomised controlled trials with a total of 245 610 subjects were included in the review..