Journal article

Clinical, histopathologic, and genetic studies in nine families with focal segmental glomerulosclerosis

K Rana, N Isbel, M Buzza, H Dagher, P Henning, G Kainer, J Savige

AMERICAN JOURNAL OF KIDNEY DISEASES | W B SAUNDERS CO | Published : 2003

Abstract

BACKGROUND: Familial forms of focal segmental glomerulosclerosis (FSGS) are caused by mutations in genes at 1q25-31 (gene for steroid-resistant nephrotic syndrome 2 [NPHS2]), 11q21-22, 19q13 (gene for alpha-actinin 4 and NPHS1), and at additional unidentified chromosomal loci. METHODS: We describe clinical and histopathologic features and results of linkage analysis in nine consecutive index cases with familial FSGS who, together with their families, were referred for genetic studies. RESULTS: Two of the index cases presented in childhood (22%) and seven cases presented in adolescence or adulthood (78%). Six of their families (67%), including the two cases with childhood-onset disease, showe..

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