Journal article

Perfusion thresholds in acute stroke thrombolysis

K Butcher, M Parsons, T Baird, A Barber, G Donnan, P Desmond, B Tress, S Davis

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2003

Abstract

BACKGROUND AND PURPOSE: Perfusion-weighted MRI has been shown to be useful in the early identification of cerebral tissue at risk of infarction during acute ischemia. Identification of threshold perfusion measures that predict infarction may assist in the selection of patients for thrombolysis. METHODS: Mean transit time (MTT), regional cerebral blood flow (rCBF), and regional cerebral blood volume (rCBV) maps were generated in 35 acute stroke patients (17 treated with tissue plasminogen activator and 18 control patients) imaged within 6 hours from symptom onset. Day 90 outcome infarcts (T2-weighted MRI) were superimposed on acute MTT, rCBF, and rCBV maps. Perfusion-weighted MRI measures wer..

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