Journal article

Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy

C Tikellis, CI Johnston, JM Forbes, WC Burns, LM Burrell, J Risvanis, ME Cooper

Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2003

Abstract

ACE2, initially cloned from a human heart, is a recently described homologue of angiotensin-converting enzyme (ACE) but contains only a single enzymatic site that catalyzes the cleavage of angiotensin I to angiotensin 1-9 [Ang(1-9)] and is not inhibited by classic ACE inhibitors. It also converts angiotensin II to Ang(1-7). Although the role of ACE2 in the regulation of the renin-angiotensin system is not known, the renin-angiotensin system has been implicated in the pathogenesis of diabetic complications and in particular in diabetic nephropathy. Therefore, the aim of this study was to assess the possible involvement of this new enzyme in the kidney from diabetic Sprague-Dawley rats to comp..

View full abstract