Journal article

Tonography demonstrates reduced facility of outflow of aqueous humor in myocilin mutation carriers

CH Wilkinson, D van der Straaten, JE Craig, MA Coote, PJ McCartney, T Stankovich, EM Stone, DA Mackey

JOURNAL OF GLAUCOMA | LIPPINCOTT WILLIAMS & WILKINS | Published : 2003

Abstract

PURPOSE: To demonstrate the effect in vivo of the myocilin gene mutation Thr377Met on outflow facility of aqueous humor, as measured by tonography. MATERIALS AND METHODS: Forty-two members of a pedigree known to carry the Thr377Met mutation were examined for glaucoma, evaluated with tonography, and screened for myocilin mutations. Tonography was used to calculate the coefficient of aqueous outflow facility (C), as well as the ratio of the resting intraocular pressure to C (P(0)/C). Subjects were reexamined for glaucoma 5 years after tonography. RESULTS: Seven subjects were excluded because of previous treatment known to alter facility of aqueous outflow. The mean outflow facility of the eyes..

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