Journal article
Two phase I studies of low dose recombinant human IL-12 with Melan-A and influenza peptides in subjects with advanced malignant melanoma.
J Cebon, E Jäger, MJ Shackleton, P Gibbs, ID Davis, W Hopkins, S Gibbs, Q Chen, J Karbach, H Jackson, DP MacGregor, S Sturrock, H Vaughan, E Maraskovsky, A Neumann, E Hoffman, ML Sherman, A Knuth
Cancer immunity : a journal of the Academy of Cancer Immunology | Published : 2003
Abstract
Preclinical studies have shown that low dose IL-12 can potentiate cytotoxic lymphocyte responses. Since previous trials have demonstrated significant toxicity from high dose recombinant human IL-12 (rhIL-12), we sought to determine an optimal biological dose for rhIL-12 at lower doses when combined with peptide antigens. Two studies were undertaken. The rhIL-12 was administered at doses of 0 (placebo), 10, 30 and 100 ng/kg, subcutaneously in one study and intravenously in the other. Apar t from IL-12 dosing, the studies were identical. Subjects had evaluable stage III or IV melanoma which expressed Melan-A by RT-PCR or immunohistochemistry. Melan-A (26-35) (EAAGIGILTV) and influenza matrix (..
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