Journal article

Heart and liver defects and reduced transforming growth factor beta 2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

KL Stenvers, ML Tursky, KW Harder, N Kountouri, S Amatayakul-Chantler, D Grail, C Small, RA Weinberg, AM Sizeland, HJ Zhu

Molecular and Cellular Biology | AMER SOC MICROBIOLOGY | Published : 2003

Abstract

The type III transforming growth factor beta (TGFbeta) receptor (TbetaRIII) binds both TGFbeta and inhibin with high affinity and modulates the association of these ligands with their signaling receptors. However, the significance of TbetaRIII signaling in vivo is not known. In this study, we have sought to determine the role of TbetaRIII during development. We identified the predominant expression sites of TbetaRIII mRNA as liver and heart during midgestation and have disrupted the murine TbetaRIII gene by homologous recombination. Beginning at embryonic day 13.5, mice with mutations in TbetaRIII developed lethal proliferative defects in heart and apoptosis in liver, indicating that TbetaRI..

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