Journal article

Integrin-linked kinase expression increases with ovarian turnour grade and is sustained by peritoneal tumour fluid

N Ahmed, C Riley, K Oliva, E Stutt, GE Rice, MA Quinn

JOURNAL OF PATHOLOGY | JOHN WILEY & SONS LTD | Published : 2003

Abstract

Integrin-linked kinase (ILK) is a serine threonine kinase, overexpression of which promotes tumour growth and invasion through deregulation of the cell cycle. This study demonstrates the relative expression of ILK in normal, benign, low-grade, and high-grade (borderline, grade I/II, and grade III) ovarian tumours of serous, mucinous, endometrioid, and clear cell types in order to assess its potential as a marker for epithelial ovarian cancer progression. Seventy-three specimens including ten normal, ten benign, 14 borderline, 17 grade I/II, and 22 grade III were evaluated by immunohistochemistry. Immunoreactive ILK was not detectable in normal ovarian surface epithelium. All 53 carcinomas st..

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