Journal article

Aspergillicins A-E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus

RJ Capon, C Skene, M Stewart, J Ford, RAJ O'Hair, L Williams, E Lacey, JH Gill, K Heiland, T Friedel

Organic & Biomolecular Chemistry | ROYAL SOC CHEMISTRY | Published : 2003


A search for new antiparasitic agents from a strain of the fungus Aspergillus carneus isolated from an estuarine sediment collected in Tasmania, Australia, yielded the known terrestrial fungal metabolite marcfortine A (1) as an exceptionally potent antiparasitic agent. This study also yielded a series of new depsipeptides, aspergillicins A-E (2-6) and the known terrestrial fungal metabolite acyl aszonalenin (7). Marcfortine A (1) and acyl aszonalenin (7) were identified by spectroscopic analysis, with comparison to literature data. Complete stereostructures were assigned to aspergillicins A-E (2-6) on the basis of detailed spectroscopic analysis, together with ESIMS analysis of the free amin..

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University of Melbourne Researchers