Journal article

Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat

M Tolcos, C Tikellis, S Rees, M Cooper, P Wookey

JOURNAL OF COMPARATIVE NEUROLOGY | WILEY | Published : 2003

Abstract

In this study, the expression of receptors for calcitonin (CTR), the CTR C1a and C1b isoforms, was investigated during development of the fetal rat central nervous system (CNS) by using in situ hybridization and immunohistochemistry. Coincident expression with both techniques was evident. Immunohistochemical evidence for the expression of the C1a isoform alone was found. Expression was first observed at embryonic day 12/13 (E12/E13) within and adjacent to the ventricular zones known to include primary matrices of proliferation, in regions of the preoptic area, anterior and posterior hypothalamus, anterior and posterior pons, medulla, and spinal cord. At later times, with the decline in the d..

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