Role of EphA4 in defining the position of a motoneuron pool within the spinal cord

Abstract

The correct assembly of the neural circuits that control movement requires the development of topographically organized pools of motoneurons within the spinal cord. The generation of a diverse array of motoneuron subtypes, which express differing transcription factors and cell-surface receptors, allows different motoneuron pools to be segregated to specific positions during development. In this investigation, we show that the Eph receptor tyrosine kinase, EphA4, appears to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord. In the spinal cord of mice deficient in EphA4, the motoneuron pool that innervates the tibialis anterior muscle of t..