Journal article
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease
G Jerums, S Panagiotopoulos, J Forbes, T Osicka, M Cooper
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2003
Abstract
Advanced glycation endproducts (AGEs) have been postulated to play a role in the development of both nephropathy and large vessel disease in diabetes. However, it is still not clear which AGE subtypes play a pathogenetic role and which of several AGE receptors mediate AGE effects on cells. This review summarises the renoprotective effect of inhibitors of AGE formation, including aminoguanidine, and of cross-link breakers, including ALT-711, on experimental diabetic nephropathy and on mesenteric vascular hypertrophy. It also demonstrates similar effects of aminoguanidine and ramipril (an angiotensin converting enzyme inhibitor) on fluorescent and immunoassayable AGE levels, renal protein kina..
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