Journal article

Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer

J Lai, J Flanagan, WA Phillips, G Chenevix-Trench, J Arnold

BRITISH JOURNAL OF CANCER | NATURE PUBLISHING GROUP | Published : 2003

Abstract

Loss of heterozygosity (LOH) on the short arm of chromosome 8, at 8p12-p23, is one of the most frequent genetic events in both breast and ovarian cancer, suggesting the location of a shared tumour suppressor gene. Microcell-mediated chromosome transfer of chromosome 8 suppresses tumorigenicity and growth of colorectal and prostate cancer cell lines, further supporting the presence of a tumour suppressor gene on 8p. We have taken a candidate gene approach to try to identify this tumour suppressor gene at 8p12-p23. BNIP3L, which has sequence homology to pro-apoptotic proteins and the ability to suppress colony formation in soft agar, is located at 8p21, within a region of ovarian cancer LOH, b..

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