Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes: Studies of plasma fibrinogen and fibrinogen gene polymorphism in the DCCT/EDIC cohort

Abstract

We examined whether plasma fibrinogen levels and the β-fibrinogen gene G-455→A polymorphism were related to microvascular or macrovascular disease in patients (n = 909) with type 1 diabetes enrolled in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC). Univariate regression showed that fibrinogen levels were correlated with BMI (r = 0.15; P < 0.0001), HbA1c (r = 0.11; P= 0.0014), total cholesterol (r = 0.17; P < 0.0001), and LDL cholesterol (r = 0.161 P < 0.0001) in all patients. In men, but not women, waist-to-hip ratio (r = 0.20; P 300 mg/24 h) was accompanied by 1.5-fold increment in plasma fibrinogen compared with patients w..