Journal article

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8( ) T cell differentiation

MMW Chong, AL Cornish, R Darwiche, EG Stanley, JF Purton, DI Godfrey, DJ Hilton, R Starr, WS Alexander, TWH Kay

IMMUNITY | CELL PRESS | Published : 2003


To determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also inserted. Using the reporter, high SOCS-1 expression was found at the CD4(+)CD8(+) stage in thymocyte development. To investigate the function of this expression, the SOCS-1 gene was specifically deleted throughout the thymocyte/T/NKT cell compartment. Unlike SOCS-1(-/-) mice, these mice did not develop lethal multiorgan inflammation but developed multiple lymphoid abnormalities, including enhanced differentiation of thymocytes toward CD8(+) T cells and very high percentages of peripheral CD8(+) T cells..

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