Journal article

Interstitial laser hyperthermia and the biological characteristics of tumor: Study in a murine model of colorectal liver metastases

V Muralidharan, M Nikfarjam, C Malcontenti-Wilson, C Christophi

JOURNAL OF CLINICAL LASER MEDICINE & SURGERY | MARY ANN LIEBERT, INC | Published : 2003

Abstract

BACKGROUND DATA: Percutaneously applied interstitial laser hyperthermia (ILH) is a minimally invasive therapy that is currently used in the treatment of liver metastases. Despite its documented efficacy, theoretical considerations and evidence based on animal studies suggest the potential for stimulating tumor growth, especially following surgery. This study investigates the influence of ILH on tumor behaviour in an animal model of colorectal liver metastases. MATERIALS AND METHODS: A model of colorectal cancer liver metastases in male inbred CBA mice was used. Laser hyperthermia was applied to tumor tissue using a bare optical quartz from a Medilas fibertom 4100 Nd:YAG surgical laser genera..

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