Journal article

Combined renin-angiotensin system blockade and dietary sodium restriction impairs cardiomyocyte contractility

P Trongtorsak, TO Morgan, LM Delbridge

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | SAGE PUBLICATIONS LTD | Published : 2003

Abstract

INTRODUCTION: Blockade of the renin-angiotensin system (RAS) by combined angiotensin-converting enzyme inhibitor and angiotensin type 1 receptor (AT(1)) antagonist treatment with reduced dietary sodium intake produces suppression of cardiac growth and regression of cardiac hypertrophy. The purpose of this study was to investigate whether cardiac growth suppression by combined RAS blockade under conditions of dietary sodium restriction is associated with cardiomyocyte atrophy and contractile dysfunction and whether this intervention modifies cardiomyocyte inotropic responsiveness to angiotensin II (Ang II). METHODS: Rats were fed a high (4% w/w) or low (0.2% w/w) NaCl diet for six days. Both ..

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