Journal article

Pseudoepitheliomatous hyperplasia in lichen sclerosus of the vulva

ES Lee, D Allen, J Scurry

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2003

Abstract

Small tentacles or separated nests of squamous cells in the dermis are not uncommonly seen in long-standing vulvar lichen sclerosus (LS) associated with epidermal thickening. We recently encountered a case where separated nests of well-differentiated squamous cells in the dermis were difficult to distinguish from squamous cell carcinoma (SCC). Further biopsies showed similar nests originating from every hair follicle. We postulated a diagnosis of multifocal pseudoepitheliomatous hyperplasia (PEH) to explain this phenomenon. Because we could find no reference to PEH in the setting of LS, we reviewed the biopsies of 92 women with extragenital and vulvar LS with and without carcinoma to determi..

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University of Melbourne Researchers