Journal article

The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition

SB Harrap, C Tzourio, F Cambien, O Poirier, S Raoux, J Chalmers, N Chapman, S Colman, S Leguennec, S MacMahon, B Neal, T Ohkubo, M Woodward

Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2003

Abstract

The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient ischemic attack who participated in the PROGRESS trial. The DD genotype was significantly (P<0.0001) less frequent in Asian subjects (Chinese and Japanese, 14.7%) than in non-Asian subjects (32.0%). Controlli..

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University of Melbourne Researchers