Journal article

Future directions in research with presymptomatic individuals carrying the gene for Huntington's disease

N Georgiou-Karistianis, E Smith, JL Bradshaw, P Chua, J Lloyd, A Churchyard, E Chiu

BRAIN RESEARCH BULLETIN | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2003

Abstract

Presymptomatic individuals carrying the gene for Huntington's disease (HD) provide researchers with a unique opportunity of learning more about the neuropathophysiology, symptom onset, behavioural functioning, and mediating factors of this fatal disease. In this review, we attempt to demonstrate that research over the last 8 years, since the isolation of the gene, has remained at large controversial. Although we are aware of some of the factors that can influence age at onset and disease progression, we are still unable to determine exactly when an individual will develop HD symptoms, and how fast these symptoms will progress. In an era rapidly advancing with respect to therapeutic intervent..

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University of Melbourne Researchers