Journal article

Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins

J Nithianantharajah, H Levis, M Murphy

NEUROBIOLOGY OF LEARNING AND MEMORY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2004

Abstract

Experience-dependent plasticity is thought to involve selective change in pre-existing brain circuits, involving synaptic plasticity. One model for looking at experience-dependent plasticity is environmental enrichment (EE), where animals are exposed to a complex novel environment. Previous studies using electron microscopy showed that EE resulted in synaptic plasticity in the visual cortex and hippocampus. However, the areas in the brain that have been examined following EE have been limited. The present study quantified potential synaptic plasticity throughout the brains of C57BL/6 mice using an enzyme-linked immunosorbent assay (ELISA) for two synaptic proteins, synaptophysin and PSD-95. ..

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