Journal article

Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development

N Carpino, WE Thierfelder, MS Chang, C Saris, SJ Turner, SF Ziegler, JN Ihle

Molecular and Cellular Biology | AMER SOC MICROBIOLOGY | Published : 2004

Abstract

The murine cytokine thymic stromal lymphopoietin (TSLP) supports the development of B220+ IgM+ immature B cells and induces thymocyte proliferation in vitro. Human TSLP, by contrast, activates CD11c+ dendritic cells, but not B or T cells. Recent studies have demonstrated that the receptor for TSLP consists of a heterodimer of the interleukin 7 (IL-7) alpha chain and a novel protein that resembles the hematopoietic cytokine receptor common gamma chain. We examined signal transduction by the gamma-like chains using chimeric receptor proteins. The cytoplasmic domain of the human, but not of the murine, gamma-like chain, activates Jak2 and Stat5 and supports the proliferation of hematopoietic ce..

View full abstract

University of Melbourne Researchers