Insulin resistance is a risk factor for progression to Type 1 diabetes

Abstract

Aims/hypothesis. Glucose homeostasis is determined by an interplay between insulin secretion and insulin action. In Type 1 diabetes, autoimmune destruction of pancreatic beta cells leads to impaired insulin secretion. However, the contribution of impaired insulin action (insulin resistance) to the development of Type 1 diabetes has received little attention. We investigated whether insulin resistance was a risk factor for progression to Type 1 diabetes. Methods. Islet-antibody-positive first-degree relatives of Type 1 diabetes probands were followed for 4.0 years (median). Insulin secretion was measured as first-phase insulin response (FPIR) to intravenous glucose. Insulin resistance was est..