Journal article

Effect of ICV injection of AT(4) receptor ligands, NLE1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats

J Lee, AL Albiston, AM Allen, FAO Mendelsohn, SE Ping, GL Barrett, M Murphy, MJ Morris, SG McDowall, SY Chai



Central administration of angiotensin IV (Ang IV) or its analogues enhance performance of rats in passive avoidance and spatial memory paradigms. The purpose of this study was to examine the effect of a single bolus injection of two distinct AT4 ligands, Nle1-Ang IV or LVV-haemorphin-7, on spatial learning in the Barnes circular maze. Mean number of days for rats treated with either Nle1-Ang IV or LVV-haemorphin-7 to achieve learner criterion is significantly reduced compared with controls (P < 0.001 and P < 0.05 respectively). This is due to enhanced ability of the peptide-treated rats to adopt a spatial strategy for finding the escape hatch. In all three measures of learning performance, (..

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