Journal article

Expression of the low-affinity neurotrophin receptor, p75(NTR), Is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination

S Petratos, MF Gonzales, MF Azari, M Marriott, RA Minichiello, KA Shipham, C Profyris, A Nicolaou, K Boyle, SS Cheema, TJ Kilpatrick

GLIA | WILEY | Published : 2004


Precursor cells have the capacity to repopulate the demyelinated brain, but the molecular mechanisms that facilitate their recruitment are largely unknown. The low-affinity neurotrophin receptor, p75(NTR), may be one of these regulators; however, its expression profile by oligodendroglia within the multiple sclerosis (MS) brain remains uncertain. We therefore assessed the expression profile of this receptor within 8 MS and 4 control brains. We found no evidence of expression of p75(NTR) by mature oligodendrocytes. Instead, we demonstrated the presence of p75(NTR) on a subgroup of NG2-positive oligodendroglial progenitors in a periventricular plaque in one MS sample. Notably, p75(NTR)-express..

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