Evidence against a synergistic effect of desmopressin with conditioning in the treatment of nocturnal enuresis

Abstract

Objective: To test the hypothesis that desmopressin facilitates acquisition of continence, we aimed to establish whether, in children with nocturnal enuresis who are desmopressin nonresponders, adjunct desmopressin increases the rate of sustained continence after treatment with a conditioning alarm. Study design: Patients with nocturnal enuresis (n = 358; age range, 6-16 years) completed a 4-week "run-in" course of intranasal desmopressin (20-40 μg). Of these, 207 defined as nonresponders (2 wet nights in 2 weeks after having achieved remission). Results: Remission rates were similar in both groups (51.5% desmopressin, 48.1% placebo; 95% CI on difference, -10%, 17%; P = .63), and relapse rat..