Effectiveness and side effects of thiazolidinediones for type 2 diabetes: Real-life experience from a tertiary hospital

Abstract

Objective: To assess effectiveness and side effects of thiazolidinediones (TZDs) as adjunctive therapy in suboptimally controlled patients with type 2 diabetes. Design and setting: Review of a prospectively recorded database at the Royal Melbourne Hospital diabetes clinic. Participants: 203 patients with type 2 diabetes who received pioglitazone or rosiglitazone between 1 May 2000 and 31 October 2002. Outcome measures: Response in glycohaemoglobin (HbA1c) level, lipid profile changes and side effects, including hypoglycaemia, weight gain, oedema and precipitation of cardiac failure. Results: Both pioglitazone and rosiglitazone improved glycaemic control, with a reduction in the HbA1c, level ..