β-Adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong osteoporosis study

Abstract

This population-based study documented β-blocker use in 59/569 cases with incident fracture and 112/775 controls. OR for fracture associated with β-blocker use was 0.68 (95% CI, 0.49-0.96). β-Blockers were associated with higher BMD at the total hip (2.5%) and UD forearm (3.6%) after adjusting for age, anthropometry, and thiazide use. β-Blocker use is associated with reduced fracture risk and higher BMD. Introduction: Animal data suggests that bone formation is under β-adrenergic control and that β-blockers stimulate bone formation and/or inhibit bone resorption. Materials and Methods: We evaluated the association between β-blocker use, bone mineral density (BMD), and fracture risk in a popu..