Journal article

Engineered allergens for immunotherapy


Current Opinion in Allergy and Clinical Immunology | Lippincott Williams & Wilkins | Published : 2004


Purpose of review Specific immunotherapy is a clinically effective causative treatment for allergic conditions. However, the reagents used for immunotherapy are crude extracts prepared from natural sources with potential life-threatening anaphylactic side effects. Molecular cloning of allergens has made it feasible to design novel therapeutic approaches for improved and safer forms of allergen-specific immunotherapy. The purpose of this review is to examine recent advances made in the last 2 years in genetic engineering of allergens for specific immunotherapy. Recent findings Genetic engineering of allergen with nil or low IgE reactivity but retained T-cell reactivity offers a novel therapeu..

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