Journal article

Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis

M Kiaei, AI Bush, BM Morrison, JH Morrison, RA Cherny, I Volitakis, MF Beal, JW Gordon

Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2004

DOI: 10.1523/JNEUROSCI.2000-04.2004

Grants

Awarded by NATIONAL INSTITUTE ON AGING

Awarded by NIA NIH HHS

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Keywords

Neurosciences & Neurology
Copper
Amyotrophic Lateral Sclerosis
Superoxide Dismutase
Spinal Cord
Phenotype
Als
Crosses, Genetic
Brain
Mice
Animals
Disease Models, Animal
Mutation, Missense
Enzyme Induction
Adenosine Triphosphatases
Mitochondria
Superoxide Dismutase-1
Neurosciences
Sod1
Cation Transport Proteins
Male
Female
Mice, Transgenic
Cu,zn-Superoxide Dismutase Mutant
Biological Transport, Active
Brain Chemistry
Longevity
Alleles
K-M
Motor-Neurons
Superoxide-Dismutase
Mice, Mutant Strains
Mice, Inbred C57bl
Science & Technology
Mottled/ Brindled
Nerve Tissue Proteins
Binding Sites
Disease
Amino Acid Substitution
Neurodegeneration
Hydrogen-Peroxide
Life Sciences & Biomedicine
Copper-Transporting Atpases
Motor Neuron