Journal article

Genomic organisation and nervous system expression of radial spoke protein 3

I Koukoulas, C Augustine, N Silkenbeumer, JM Gunnersen, HS Scott, SS Tan

GENE | ELSEVIER | Published : 2004


Following their generation in the germinal zones, young neurons of the neocortex, hippocampus and cerebellum undergo long-distance migration to reach their final destinations. This locomotive activity depends on active deployment of cytoskeletal elements including the microtubule apparatus. In this study, we report the identification and expression of radial spoke protein 3 (RSP3), a member of a protein cluster responsible for anchoring and modifying dynein motor activity known to be crucial to microtubule sliding. The mouse RSP3 gene consists of eight exons and seven introns and spans over 230 kb. The genomic organisations of the human and rat RSP3 genes are similar although they span appro..

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