Journal article

Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen

JA Pearce, T Triglia, AN Hodder, DC Jackson, AF Cowman, RF Anders

INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2004

Abstract

Merozoite surface protein 1 (MSP1) is a highly polymorphic Plasmodium falciparum merozoite surface protein implicated in the invasion of human erythrocytes during the asexual cycle. It forms a complex with MSP6 and MSP7 on the merozoite surface, and this complex is released from the parasite around the time of erythrocyte invasion. MSP1 and many other merozoite surface proteins contain dimorphic elements in their protein structures, and here we show that MSP6 is also dimorphic. The sequences of eight MSP6 genes indicate that the alleles of each dimorphic form of MSP6 are highly conserved. The smaller 3D7-type MSP6 alleles are detected in parasites from all malarious regions of the world, whe..

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