Intrinsic primary afferent neurones of the digestive tract

Abstract

Intrinsic primary afferent neurones of the intestine are specialized neurones that encode information about the state of the intestine by transducing mechanical and chemical stimuli that reflect tension in the gut wall and the chemical nature of its contents. They connect with interneurones and motor neurones in the gut to form the circuits of intrinsic muscle motor, secretomotor and vasomotor reflexes. A large range of ionic currents occur in these neurones. The neurones have voltage-activated inward sodium currents (both tetrodotoxin-sensitive and tetrodotoxin-insensitive) and inward calcium currents. Calcium entering during the action potential activates a slow afterhyperpolarizing potass..