Journal article

Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes

MZ Smith, CJ Dale, R De Rose, I Stratov, CS Fernandez, AG Brooks, J Weinfurter, K Krebs, C Riek, DI Watkins, DH O'Connor, SJ Kent

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2005

Abstract

Successful human immunodeficiency virus (HIV) vaccines will need to induce effective T-cell immunity. We studied immunodominant simian immunodeficiency virus (SIV) Gag-specific T-cell responses and their restricting major histocompatibility complex (MHC) class I alleles in pigtail macaques (Macaca nemestrina), an increasingly common primate model for the study of HIV infection of humans. CD8+ T-cell responses to an SIV epitope, Gag164-172KP9, were present in at least 15 of 36 outbred pigtail macaques. The immunodominant KP9-specific response accounted for the majority (mean, 63%) of the SIV Gag response. Sequencing from six macaques identified 7 new Mane-A and 13 new Mane-B MHC class I allel..

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