Journal article

Quantifying trade-offs: quality of life and quality-adjusted survival in a randomised trial of chemotherapy in postmenopausal patients with lymph node-negative breast cancer

J Bernhard, D Zahrieh, AS Coates, RD Gelber, M Castiglione-Gertsch, E Murray, JF Forbes, L Perey, J Collins, R Snyder, CM Rudenstam, D Crivellari, A Veronesi, B Thurlimann, MF Fey, KN Price, A Goldhirsch, C Hurny

BRITISH JOURNAL OF CANCER | NATURE PUBLISHING GROUP | Published : 2004

Abstract

We evaluated quality of life (QL) and quality-adjusted survival in International Breast Cancer Study Group Trial IX, a randomised trial including 1669 eligible patients receiving tamoxifen for 5 years or three prior cycles of cyclophosphamide, methotrexate and 5-fluorouracil (CMF) followed by 57 months tamoxifen. During the time with CMF toxicity (Tox), without symptoms and toxicity (TWiST), and following relapse (Rel), patients scored their QL indicators and a utility indicator for subjective health estimation between 'perfect' and 'worst' health. Scores were averaged within Tox, TWiST and Rel and transformed to utilities. Mean durations for the three transition times were weighted with uti..

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