Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma

Abstract

Background. Sinonasal undifferentiated carcinoma (SNUC) is an uncommon malignancy associated with poor prognosis. The optimal treatment approach for SNUC has not been established was performed. Methods. A retrospective review of all patients with SNUC seen at the Peter MacCallum Cancer Centre over a 12-year period. Results. Ten patients with SNUC were identified, with nine having locally advanced disease (T4). Seven were treated with three cycles of platinum and 5-fluorouracil followed by radiation with two cycles of concurrent platinum. In these seven patients, the 2-year progress on-free survival was 43% (95% CI, 11% to 82%) and the 2-year overall survival was 64% (95% CI, 23% to 91%). One..