Journal article
The use of CRP for diagnosing infections in young infants <3 months of age in developing countries
A Palmer, JB Carlin, J Freihorst, S Gatchalian, L Muhe, K Mulholland, MW Weber, S Gove, P Margolis, F McCaul, S Parker, C John, P Byass, O Ogunlesi, M Manary, R Adegbola, H Whittle, O Secka, B Sam, D Hazlett Show all
Annals of Tropical Paediatrics | MANEY PUBLISHING | Published : 2004
Abstract
The diagnosis of severe bacterial infection in young infants in developing countries is difficult because of the lack of sensitivity and specificity of the presenting symptoms and signs. Whether C-reactive protein (CRP) might help with the early detection of neonatal sepsis was investigated in a prospective study in The Gambia, Ethiopia and The Philippines. Infants <3 months of age with symptoms or signs of possible sepsis were evaluated; CRP was measured and assessed for its ability to predict proven invasive bacterial infection. Of 966 children <3 months of age, 54 had a positive blood culture, 13 a positive CSF culture, 15 a positive blood and CSF culture and 884 had negative cultures. Me..
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