Journal article

Eki2 is upregulated specifically in the testis during mouse sex determination

TM Hurley, PJ McClive, MA Sarraj, AH Sinclair

GENE EXPRESSION PATTERNS | ELSEVIER SCIENCE BV | Published : 2004

Abstract

We have identified a gene with gonad restricted expression throughout mouse development, which is orthologous to human EKI2 (ethanolamine kinase 2). Our studies showed that mouse Eki2 expression became upregulated in the male gonad during the period of sex determination. Expression was restricted to the Sertoli cells of the developing testis. Eki2 has sequence similarity to ethanolamine (73%) and choline kinases (54%).