Eki2 is upregulated specifically in the testis during mouse sex determination

Abstract

We have identified a gene with gonad restricted expression throughout mouse development, which is orthologous to human EKI2 (e thanolamine ki nase 2). Our studies showed that mouse Eki2 expression became upregulated in the male gonad during the period of sex determination. Expression was restricted to the Sertoli cells of the developing testis. Eki2 has sequence similarity to ethanolamine (73%) and choline kinases (54%). © 2003 Elsevier B.V. All rights reserved.