Journal article

Super high flux hemodialysis at high dialysate flows: An ex vivo assessment

WCR Lee, S Uchino, N Fealy, I Baldwin, S Panagiotopoulos, H Goehl, S Morgera, HH Neumayer, R Bellomo

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | SAGE PUBLICATIONS LTD | Published : 2004

Abstract

BACKGROUND AND OBJECTIVES: The removal of cytokines by standard hemofiltration is limited. Super high flux membranes may significantly improve removal even when used in dialysis mode. We sought to measure cytokine clearance using a large surface super high-flux membrane and a standard hemodialysis setting. SETTING: ICU laboratory of a tertiary institution. SUBJECTS: Six healthy volunteers. METHODS: Blood form healthy volunteers was incubated for 4 hours with E. coli endotoxin to stimulate cytokine production. Cytokine containing blood was then circulated through a dialysis circuit at 3 different dialysate flow rates. Blood and dialysate were sampled for cytokine and albumin measurements and ..

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