Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study

Abstract

Objective: To evaluate the effect of dietary folate intake on the relation between alcohol consumption and breast cancer risk. Design: Prospective cohort study. Setting: Melbourne, Australia. Participants: 17 447 Anglo-Australian women resident in Melbourne, aged 40-69 years at recruitment in 1990-4, and followed up until 31 December 2003. Main outcome measure: Invasive breast cancers diagnosed during follow-up and ascertained through the Victorian cancer registry. Results: 537 invasive breast cancers were diagnosed. Compared with lifetime abstainers, the hazard ratio for breast cancer in women who consumed an average of 40 g or more of alcohol daily at baseline was 1.41 (95% confidence inte..