Journal article

Mph2 expression in germinal zones of the mouse brain

MH Kim, JM Gunnersen, SS Tan

DEVELOPMENTAL DYNAMICS | WILEY | Published : 2005

Abstract

The telencephalon develops from a seemingly homogeneous population of precursor cells that generates neurons with divergent properties and cell fates. An important question concerns the genetic control of cell states belonging to different generations. Mph2 was identified by serial analysis of gene expression as a differentially expressed gene during cortical development. Belonging to the Polycomb group, Mph2 may be involved in transcriptional repression of cell states from one generation to the next. Here, we use in situ hybridization to determine the spatial localization of Mph2 expression in the developing nervous system. Mph2 expression evident in proliferating precursor cell populations..

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