Association between erythropoietin in cord blood of twins and size at birth: Does it relate to gestational factors or to factors during labor or delivery?
R Morley, VM Moore, T Dwyer, JA Owens, MP Umstad, JB Carlin
PEDIATRIC RESEARCH | INT PEDIATRIC RESEARCH FOUNDATION, INC | Published : 2005
We hypothesized that cord blood erythropoietin (EPO), a marker of fetal hypoxia, relates to gestational factors and not solely those associated with delivery. We investigated the association between birth weight SD score (SDS) and cord blood EPO in 290 twins (145 pairs), assessing the influence of gestational versus perinatal factors by comparing the association in those who were delivered by elective cesarean (CS) with that in other delivery modes. Blood EPO values were skewed, so geometric means are presented and log EPO values were used in statistical models. The birth size-EPO association was estimated in mixed-effects models that included terms that represented difference in log EPO and..View full abstract