Journal article

Chronic hepatitis B: recommendations for therapy based on the natural history of disease in Australian patients

SJ Bell, A Lau, A Thompson, KJR Watson, B Demediuk, G Shaw, RY Chen, A Ayres, L Yuen, A Bartholomeusz, SA Locarnini, PV Desmond

Journal of Clinical Virology | ELSEVIER SCIENCE BV | Published : 2005

Abstract

BACKGROUND: Chronic hepatitis B infection (CHB) is a major health problem in Australia and worldwide. CHB is associated with significant long-term morbidity and mortality. Well tolerated treatment is now available, however the development of resistance is common and the optimal timing of treatment is yet to be determined. Identifying the factors that influence the natural history of CHB may help determine which patients need treatment and when to start it. OBJECTIVE: To determine the demographics, clinical features and virological profile of Australian patients infected with CHB and the influence of these factors on disease activity and severity. STUDY DESIGN: Review of prospectively collect..

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